Hints That Statins Reduce Colon Cancer Risk Finally Being Put to the Test
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چکیده
منابع مشابه
Statins Reduce Inflammation, DVT, Osteoporosis, and Colon Cancer MECHANISMS OF STATINS
34 BACKGROUND Statin medications lower serum cholesterol by competitively inhibiting HMG-CoA reductase. By this mechanism, statins effectively lower LDL cholesterol and reduce the risk of ischemic heart disease and stroke. The relative safety of statins has led to their widespread use, but recent research suggests that statins may have additional important therapeutic effects via other molecula...
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Personalized heart muscle cells made from stem cells in the laboratory could be used to check an individual's response to potential new drugs before clinical trials.
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A diet high in red meat increases risk of colon cancer. But eating resistant starch—a carbohydrate that acts like fiber—may reduce that risk, according to a study in August’s Cancer Prevention Research. “Red meat and resistant starch have opposite effects on the colorectal cancer– promoting microRNAs,” said first author Karen Humphreys, Ph.D., a research associate at the Flinders Centre for Inn...
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The study by Frolich et al1 in this issue of Circulation adds to the body of evidence that statins as a class of drugs have effects that reduce the chance of cancer initiation and progression, recapitulating findings showing reductions in cancer-related mortality in statin users in other major malignancies such as breast and prostate cancer.2,3 The authors are explicit in recognizing the flaws ...
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Inulin is extracted from the chicory root. It is a set of fructans with its monomers linked by means of beta(2-1) bonds. This linkage cannot be hydrolysed by either pancreatic or by brush border digestive enzymes in the upper intestinal tract of humans. As such the carbohydrates arrive in the colon, where they are fermented by bifidobacteria and other lactic acid producing bacteria, thus enhanc...
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ژورنال
عنوان ژورنال: JNCI Journal of the National Cancer Institute
سال: 2011
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djr057